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Specific expression of GPR56 by human cytotoxic lymphocytes


We here report the existence of a new cluster of adhesion-GPCRs in human immune cells. Analysis of a comprehensive immune cell transcriptome dataset indicated that expression of the closely related receptors, GPR56, GPR97, and GPR114, is associated with single lymphocyte and granulocyte subsets. Applying flow cytometric analysis with newly generated mAb, we show that expression of GPR56 is restricted to cytotoxic NK and T lymphocytes, including CD8(+), CD4(+), and gammadelta T cells. Primary infection with human CMV, which generates a vast population of CD8(+) T cells with an effector phenotype, induced a strong increase in GPR56 expression in virus-specific CD8(+) T cells that remained detectable during latency. In NK-92 cells, ectopic expression of GPR56 inhibited spontaneous and SDF-1-stimulated cell migration. Our data suggest that GPR56 expression is a common trait of human cytotoxic lymphocytes and might affect the migratory properties of these cells.

Type Journal
ISBN 1938-3673 (Electronic) 0741-5400 (Linking)
Authors Peng, Y. M.; van de Garde, M. D.; Cheng, K. F.; Baars, P. A.; Remmerswaal, E. B.; van Lier, R. A.; Mackay, C. R.; Lin, H. H.; Hamann, J.:
Published Date 2011-10-01
Published Volume 90
Published Issue 4
Published Pages 735-40
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version