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Estrogen receptor degradation: a CUE for endocrine resistance?

Abstract

Despite the undoubted success of adjuvant endocrine therapies that target the estrogen receptor pathway, not all women with estrogen receptor-positive breast cancer respond to these therapies, and many who initially respond will subsequently relapse. Deregulation of various aspects of estrogen receptor signaling has been highlighted as a mechanism of resistance and as a basis for alternative therapeutic approaches. However, a recent publication refocuses attention on the estrogen receptor itself by showing that the ubiquitin-binding CUE domain-containing protein 2 is a regulator of estrogen receptor protein degradation and a marker of endocrine resistance in breast cancer.

Type Journal
Authors Musgrove, E.A.
Responsible Garvan Author
Publisher Name BREAST CANCER RES
Published Date 2011-09-01
Published Volume 13
Published Issue 4
Published Pages 312
Status Published in-print
DOI bcr2914 [pii] 10.1186/bcr2914
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21861853
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11101