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Immunotherapy of allergic diseases by bacterial products

Abstract

Allergic diseases are characterized by excessive immunoglobulin E (IgE) production, mast cell degranulation, tissue eosinophilia and mucus hypersecretion. These responses also take place during infection with multicellular parasites, and are linked to the production of a characteristic set of cytokines by T helper (Th)2 cells. By contrast, many other microbial infections are associated with cytokine production by Th1 or Th17 cells. There have been extensive efforts to subvert the Th2 responses of allergic diseases by treatment with microbial products.

Type Journal
ISBN 1440-1711 (Electronic) 0818-9641 (Linking)
Authors Sewell, W. A.; Thomas, W. R.:
Responsible Garvan Author A/Prof William Sewell
Publisher Name IMMUNOLOGY AND CELL BIOLOGY
Published Date 2011-10-06
Published Volume 89
Published Issue 7
Published Pages 749-50
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/21445086
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11108