Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells
A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.
|Authors||Brooke, D.G.; Shelley, E.J.; Roberts, C.G.; Denny, W.A.; Sutherland, R.L.; Butt, A.J.|
|Publisher Name||BIOORGANIC & MEDICINAL CHEMISTRY|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22044656|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/11118|