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Reciprocal regulation of bone and energy metabolism

Abstract

BACKGROUND: The primary relationship affecting skeletal tissue involves the association between fat mass and bone mass. However, there is some complexity in this relationship that may be explained by endocrine and neural pathways representing direct, reciprocal signalling between fat and bone tissue. For example, leptin signalling can directly stimulate osteoblastic differentiation and osteoblast proliferation and mineralization, but it also has central signalling actions in that it decreases cancellous bone volume. A novel regulatory loop between bone and adipose tissue suggests that uncarboxylated osteocalcin may affect energy homeostasis and afford a pathway by which fat mass can be regulated by bone mass. CONCLUSIONS: The multilayered and complex signals between fat and bone tissue involve both direct and indirect pathways. The endocrinologic nature of these signals highlights an emerging trend in medicine: identification of organ-based endocrine signals.

Type Journal
ISBN 1663-2826 (Electronic)
Authors Baldock, P.;
Responsible Garvan Author A/Prof Paul Baldock
Publisher Name Hormone Research in Paediatrics
Published Date 2011-01-01
Published Volume 76 Suppl 1
Published Pages 7-11
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21778741
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11154