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PINA v2.0: Mining Interactome modules.

Abstract

The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes a database of unified protein-protein interaction data integrated from six manually curated public databases, and a set of built-in tools for network construction, filtering, analysis and visualization. The second version of PINA enhances its utility for studies of protein interactions at a network level, by including multiple collections of interaction modules identified by different clustering approaches from the whole network of protein interactions (?Interactome?) for six model organisms. All identified modules are fully annotated by enriched Gene Ontology terms, KEGG pathways, Pfam domains and the chemical and genetic perturbations collection from MSigDB. Moreover, a new tool is provided for module enrichment analysis in addition to simple query function. The Interactome data is also available on the web site for further bioinformatics analysis. PINA is freely accessible at http://cbg.garvan.unsw.edu.au/pina/.

Type Electronic article
Authors Cowley, M.J.; Pinese, M.; Kassahn, K.S.; Waddell, N.; Pearson, J.V.; Grimmond, S.M.; Biankin, A.V.; Hautaniemi, S.; Wu, J.
Responsible Garvan Author Dr Mark Cowley
Publisher Name NUCLEIC ACIDS RESEARCH
Published Date 2012-01-01
Published Volume 40
Published Issue D11
Published Pages D862?D865
Status Published in-print
DOI gkr967 [pii] 10.1093/nar/gkr967
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22067443
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11190