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The spiral ganglion: connecting the peripheral and central auditory systems


In mammals, the initial bridge between the physical world of sound and perception of that sound is established by neurons of the spiral ganglion. The cell bodies of these neurons give rise to peripheral processes that contact acoustic receptors in the organ of Corti, and the central processes collect together to form the auditory nerve that projects into the brain. In order to better understand hearing at this initial stage, we need to know the following about spiral ganglion neurons: (1) their cell biology including cytoplasmic, cytoskeletal, and membrane properties, (2) their peripheral and central connections including synaptic structure; (3) the nature of their neural signaling; and (4) their capacity for plasticity and rehabilitation. In this report, we will update the progress on these topics and indicate important issues still awaiting resolution.

Type Journal
ISBN 1878-5891 (Electronic) 0378-5955 (Linking)
Authors Nayagam, B. A.; Muniak, M. A.; Ryugo, D. K.;
Garvan Authors Prof David Ryugo
Publisher Name HEARING RES
Published Date 2011-05-03 00:00:00
Published Volume 278
Published Issue 1-2
Published Pages 2-20
Status Published In-print
OpenAccess Link Nayagam Her Res_.pdf