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Synaptic morphology and the influence of auditory experience


The auditory experience is crucial for the normal development and maturation of brain structure and the maintenance of the auditory pathways. The specific aims of this review are (i) to provide a brief background of the synaptic morphology of the endbulb of Held in hearing and deaf animals; (ii) to argue the importance of this large synaptic ending in linking neural activity along ascending pathways to environmental acoustic events; (iii) to describe how the re-introduction of electrical activity changes this synapse; and (iv) to examine how changes at the endbulb synapse initiate trans-synaptic changes in ascending auditory projections to the superior olivary complex, the inferior complex, and the auditory cortex.

Type Journal
ISBN 1878-5891 (Electronic) 0378-5955 (Linking)
Authors O'Neil, J. N.; Connelly, C. J.; Limb, C. J.; Ryugo, D. K.;
Published Date 2011-02-12
Published Volume 279
Published Issue 1-2
Published Pages 118-30
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version