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Elf5, hormones and cell fate.

Abstract

Recent elucidation of the stem and progenitor cell hierarchies operative during normal tissue and organ development has provided a foundation for the development of new insights into the disease process. These hierarchies are established by genetic mechanisms that specify and determine cell fate to act as cell-clade gatekeepers, upon which all multicellular organisms depend for viability. Perturbation of this gatekeeper function characterizes developmentally based disease such as cancer. Here we review the emerging gatekeeper and master regulator roles of the ETS transcription factor Elf5 in a number of diverse developmental scenarios and show how this function intersects with hormonal and growth factor regulation of these processes.

Type Journal
Authors Lee, H.J.; Ormandy, C.J.
Publisher Name TRENDS IN ENDOCRINOLOGY AND METABOLISM
Published Date 2012-01-01 00:00:00
Published Volume 23
Published Issue 6
Published Pages 292-298
Status Published in-print
DOI S1043-2760(12)00033-1 [pii] 10.1016/j.tem.2012.02.006
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/22464677
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11323