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Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance


The biological activity of interleukin (IL)-2 and other cytokines in vivo can be augmented by binding to certain anti-cytokine monoclonal antibodies (mAb). Here, we review evidence on how IL-2/anti-IL-2 mAb complexes can be used to cause selective stimulation and expansion of certain T-cell subsets. With some anti-IL-2 mAbs, injection of IL-2/mAb complexes leads to expansion of CD8 T effector cells but not CD4 T regulatory cells (Tregs); these complexes exert less adverse side effects than soluble IL-2 and display powerful antitumor activity. Other IL-2/mAb complexes have minimal effects on CD8 T cells but cause marked expansion of Tregs. Preconditioning mice with these complexes leads to permanent acceptance of MHC-disparate pancreatic islets in the absence of immunosuppression.

Type Journal
Authors Boyman, O.; Krieg, C.; Letourneau, S.; Webster, K.; Surh, C. D.; Sprent, J.:
Responsible Garvan Author Prof Jonathan Sprent
Published Date 2012-06-01
Published Volume 44
Published Issue 4
Published Pages 1032-4
Status Published in-print
DOI 10.1016/j.transproceed.2012.01.093
URL link to publisher's version
OpenAccess link to author's accepted manuscript version