The role of interleukin-2 during homeostasis and activation of the immune system.
Interleukin-2 (IL-2) signals influence various lymphocyte subsets during differentiation, immune responses and homeostasis. As discussed in this Review, stimulation with IL-2 is crucial for the maintenance of regulatory T (T(Reg)) cells and for the differentiation of CD4(+) T cells into defined effector T cell subsets following antigen-mediated activation. For CD8(+) T cells, IL-2 signals optimize both effector T cell generation and differentiation into memory cells. IL-2 is presented in soluble form or bound to dendritic cells and the extracellular matrix. Use of IL-2 - either alone or in complex with particular neutralizing IL-2-specific antibodies - can amplify CD8(+) T cell responses or induce the expansion of the T(Reg) cell population, thus favouring either immune stimulation or suppression.
|Authors||Boyman, O.; Sprent, J.|
|Publisher Name||NATURE REVIEWS IMMUNOLOGY|
|Published Date||2012-02-22 00:00:00|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/22343569|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/11335|