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Clearing the complexity: immune complexes and their treatment in lupus nephritis


Systemic lupus erythematosus (SLE) is a classic antibody-mediated systemic autoimmune disease characterised by the development of autoantibodies to ubiquitous self-antigens (such as antinuclear antibodies and antidouble-stranded DNA antibodies) and widespread deposition of immune complexes in affected tissues. Deposition of immune complexes in the kidney results in glomerular damage and occurs in all forms of lupus nephritis. The development of nephritis carries a poor prognosis and high risk of developing end-stage renal failure despite recent therapeutic advances. Here we review the role of DNA-anti-DNA immune complexes in the pathogenesis of lupus nephritis and possible new treatment strategies aimed at their control.

Type Journal
ISBN 1178-7058 (Electronic) 1178-7058 (Linking)
Authors Toong, C.; Adelstein, S.; Phan, T. G.;
Responsible Garvan Author Prof Tri Phan
Publisher Name Int J Nephrol Renovasc Dis
Published Date 2011-01-01
Published Volume 4
Published Pages 17-28
Status Published in-print
OpenAccess link to author's accepted manuscript version