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Drosophila as a tool for studying the conserved genetics of pain

Abstract

Survival of all animals depends on an accurate representation of the world, and an organism must be capable of prioritizing and responding to potentially hazardous conditions. This ability is dependent on nociception, the sensory process allowing animals to detect and avoid potentially harmful stimuli. Nociception is the sensory process that results in the subjective experience of ""pain"" in humans. Due to its vital and broad role in animal biology, pain/nociception is a complex, whole body physiological process that is under stringent evolutionary pressure. Here we discuss the utility of Drosophila melanogaster as an emerging model organism for studying the conserved genetics of nociception, particularly with respect to recently developed high throughput Drosophila ""pain"" paradigms.

Type Journal
Authors Milinkeviciute, G.; Gentile, C.; Neely, G. G.
Responsible Garvan Author
Publisher Name CLINICAL GENETICS
Published Date 2012-08-14 00:00:00
Published Volume 82
Published Issue 4
Published Pages 359-66
Status Published in-print
DOI 10.1111/j.1399-0004.2012.01941.x
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/22880632
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11424