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Bystanders not so innocent after all


Interleukin 27 (IL-27) regulates immune responses, including T helper 17 (Th17) cell activity. In this issue of Immunity, Hirahara et al. (2012) demonstrate that IL-27 suppresses Th17 cells in trans through induction of the inhibitory ligand PD-L1 on bystander T cells.

Type Journal
Authors Batten, M.; Ghilardi, N.
Responsible Garvan Author Dr Marcel Batten
Publisher Name IMMUNITY
Published Date 2012-06-29
Published Volume 36
Published Issue 6
Published Pages 901-3
Status Published in-print
DOI S1074-7613(12)00238-5 [pii] 10.1016/j.immuni.2012.06.001
URL link to publisher's version
OpenAccess link to author's accepted manuscript version