TGF-beta puts the brakes on homeostatic proliferation
The cellular mechanism by which the cytokine TGF-b maintains the homeostasis of mature T cells and prevents the emergence of severe lethal lymphoproliferative disease has remained obscure. It is now shown that TGF-b restrains the homeostatic T cell proliferation driven by self ligands from erupting into overt autoimmunity.
|Authors||Surh, C. D.; Sprent, J.:|
|Publisher Name||NAT IMMUNOL|
|Published Date||2012-06-19 00:00:00|