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TGF-beta puts the brakes on homeostatic proliferation


The cellular mechanism by which the cytokine TGF-b maintains the homeostasis of mature T cells and prevents the emergence of severe lethal lymphoproliferative disease has remained obscure. It is now shown that TGF-b restrains the homeostatic T cell proliferation driven by self ligands from erupting into overt autoimmunity.

Type Journal
Authors Surh, C. D.; Sprent, J.:
Garvan Authors Prof Jonathan Sprent
Publisher Name NAT IMMUNOL
Published Date 2012-06-19 00:00:00
Published Volume 13
Published Issue 7
Published Pages 628-30
Status Published In-print
OpenAccess Link