TGF-beta puts the brakes on homeostatic proliferation
The cellular mechanism by which the cytokine TGF-b maintains the homeostasis of mature T cells and prevents the emergence of severe lethal lymphoproliferative disease has remained obscure. It is now shown that TGF-b restrains the homeostatic T cell proliferation driven by self ligands from erupting into overt autoimmunity.
|Authors||Surh, C. D.; Sprent, J.:|
|Publisher Name||NATURE IMMUNOLOGY|
|DOI||10.1038/ni.2345 ni.2345 [pii]|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/22713819|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/11429|