Mouse models of inflammatory bowel disease - insights into the mechanisms of inflammation-associated colorectal cancer.
The association between chronic inflammation and cancer has been noted for at least a century but the exact molecular mechanisms of cancer initiation and promotion by such inflammation are still poorly understood. The gastrointestinal tract is a unique organ where maintaining a balance between the colonic epithelial cells, the immune system and a fine-tuned response to the resident microflora is crucial for preserving the gut homeostasis. A breakdown of the tight interdependent regulation of the epithelium?immunity?microbiota triangle leads to inflammatory bowel disorders and may promote cancer. This review focuses on inflammation-associated colorectal cancer in mouse models of the disease and highlights emerging research trends.
|Authors||Mladenova, D.; Kohonen-Corish, M.R.J.|
|Responsible Garvan Author|
|Publisher Name||IN VIVO|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/22773577|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/11470|