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Mouse models of inflammatory bowel disease - insights into the mechanisms of inflammation-associated colorectal cancer.


The association between chronic inflammation and cancer has been noted for at least a century but the exact molecular mechanisms of cancer initiation and promotion by such inflammation are still poorly understood. The gastrointestinal tract is a unique organ where maintaining a balance between the colonic epithelial cells, the immune system and a fine-tuned response to the resident microflora is crucial for preserving the gut homeostasis. A breakdown of the tight interdependent regulation of the epithelium?immunity?microbiota triangle leads to inflammatory bowel disorders and may promote cancer. This review focuses on inflammation-associated colorectal cancer in mouse models of the disease and highlights emerging research trends.

Type Journal
Authors Mladenova, D.; Kohonen-Corish, M.R.J.
Responsible Garvan Author Dr Dessislava Mladenova
Publisher Name IN VIVO
Published Date 2012-07-10
Published Volume 26
Published Issue 4
Published Pages 627-46
Status Published in-print
DOI 26/4/627 [pii]
URL link to publisher's version
OpenAccess link to author's accepted manuscript version