Copy-number-aware differential analysis of quantitative DNA sequencing data
Developments in microarray and high throughput sequencing (HTS) technologies have resulted in a rapid expansion of research into epigenomic changes that occur in normal development and in the progression of disease, such as cancer. Not surprisingly, copy number variation (CNV) has a direct effect on HTS read densities and can therefore bias differential detection results. We have developed a flexible approach called ABCD-DNA (Affinity Based Copy-number-aware Differential quantitative DNA sequencing analyses) that integrates CNV and other systematic factors directly into the differential enrichment engine.
|ISBN||1549-5469 (Electronic) 1088-9051 (Linking)|
|Authors||Robinson, M. D.; Strbenac, D.; Stirzaker, C.; Statham, A. L.; Song, J. Z.; Speed, T. P.; Clark, S. J.;|
|Responsible Garvan Author|
|Publisher Name||GENOME RESEARCH|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/22879430|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/11490|