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Impact of percentage of positive biopsy cores on biochemical outcome in patients treated with low-dose rate (Iodine-125) brachytherapy for prostate cancer.


To investigate the significance of the percentage of positive biopsy cores (PPBCs) in predicting the biochem- ical outcome in patients with clinically localised prostate cancer undergoing low-dose rate brachytherapy (LDRB). ? A total of 326 consecutive patients underwent LDRB between February 1997 and January 2007. The cohort consisted of 68.7%, 30.4% and 0.9% of low-, intermediate- and high-risk groups respectively as defined by the D?Amico classifica- tion. Patients were stratified according to PPBCs (<35%, 35-50%, >50%). ? Of the 326 men, 316 (97%) met the study criteria and were included in the analysis. The median follow-up was 66.3 (12.9-147.5) months. Thirty-eight men (12%) developed evidence of biochemical relapse as defined by the Phoenix defi- nition at a median of 44.5 (4-133) months. The overall 5-year and 10-year biochemical relapse-free rate (BRFR) was 91.9% (95% CI 87.9% to 94.6%) and 76.9% (95% CI 66% to 84%) respectively. ? On univariate analysis, Gleason score (p=0.03), D?Amico risk groups (p=0.004) and PPBCs (p=0.001) were significant predictors of biochemical failure. In the multivariate model, the PPBCs (p=0.0006) and pretreatment PSA (p=0.004) were the only variables that predicted for biochemical failure. The 5-year biochemical relapse-free rate was 93.5%, 93.0% and 76.5% for the PPBCs <35%, 35%-50% and >50% respectively (p=0.001). Conclusions: ? The PPBC is an important independent predictor of the 5-year biochemical relapse-free survival after LDRB. This finding suggests that patients with high volume tumour are at increased risk of biochemical failure with LDRB. Prostate cancer research at the Garvan Institute/St Vin- cent's Hospital is supported in part by grants from the National Health and Medical Research Council of Australia, Cancer Institute New South Wales, Prostate Cancer Founda- tion of Australia, Australia Cancer Research Foundation, St Vincent's Prostate Cancer Centre, the RT Hall Trust and the Petre Foundation.

Type Journal
Authors Yuen, C.; Hossack, T.; Haynes, A-M.; Pe Benito, R.A.; Matthews, J.; Fogarty, G.; Jagavkar, R.; Brenner, P.; Stricker, P.;
Publisher Name Open Prostate Cancer Journal
Published Date 2012-12-01
Published Volume 5
Published Pages 15-19
Status Published in-print
DOI DOI: 10.2174/1876822901205010015
URL link to publisher's version
OpenAccess link to author's accepted manuscript version