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The role of regulatory RNA in cognitive evolution


The evolution of the human brain has resulted in the emergence of higher-order cognitive abilities, such as reasoning, planning and social awareness. Although there has been a concomitant increase in brain size and complexity, and component diversification, we argue that RNA regulation of epigenetic processes, RNA editing, and the controlled mobilization of transposable elements have provided the major substrates for cognitive advance. We also suggest that these expanded capacities and flexibilities have led to the collateral emergence of psychiatric fragilities and conditions. Trends Cogn Sci. 2012 Oct;16(10):497-503. doi: 10.1016/j.tics.2012.08.007. Epub 2012 Aug 30.

Type Journal
ISBN 1879-307X (Electronic) 1364-6613 (Linking)
Authors Barry, G.; Mattick, J. S.;
Responsible Garvan Author Prof John Mattick
Published Date 2012-01-01
Published Volume 16
Published Issue 10
Published Pages 497-503
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version