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New insights into signalling networks regulating breast cancer stem cells


ABSTRACT: In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target. Breast Cancer Res. 2012 Sep 21;14(5):321.

Type Journal
ISBN 1465-542X (Electronic) 1465-5411 (Linking)
Authors Swarbrick, A.; Daly, R. J.;
Responsible Garvan Author
Published Date 2012-01-01
Published Volume 14
Published Issue 5
Published Pages 321
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version