New insights into signalling networks regulating breast cancer stem cells
ABSTRACT: In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target. Breast Cancer Res. 2012 Sep 21;14(5):321.
|ISBN||1465-542X (Electronic) 1465-5411 (Linking)|
|Authors||Swarbrick, A.; Daly, R. J.;|
|Responsible Garvan Author|
|Publisher Name||BREAST CANCER RES|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/22999218|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/11622|