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Genetics, calcium intake and osteoporosis


Genetic factors explain a high proportion of the age-specific differences in bone density, size and turnover. The potential for interaction between hormonal, diet and lifestyle factors is likely to be important. Common allelic variation in the VDR is an example of normal gene variants altering Ca homoeostasis, with effects on body and bone size as well as bone density. The VDR findings suggesting interactions between genetic and nutritional factors are an important target for future research. These studies are complicated by the potential for effects of gene-gene interactions and of undefined environmental factors. These problems notwithstanding, considerations of environmental and nutritional contributions, such as Ca intake and vitamin D status, will be critical in interpreting these genetic pathways and in 'personalizing' nutritional recommendations.

Type Journal
ISBN 0029-6651 (Print)
Authors Eisman, J. A. :
Publisher Name Proc Nutr Soc
Published Date 1998-01-01
Published Volume 57
Published Issue 2
Published Pages 187-93
Status Published in-print
URL link to publisher's version