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Pancreatic beta-cell failure in the pathogenesis of type 2 diabetes

Abstract

As the worldwide prevalence of type 2 diabetes continues to rise, there is mounting evidence that failure of the cells which make insulin - termed pancreatic beta (or beta) cells, play a fundamental role at all stages in the pathogenesis. Beta-cell defects such as loss of the initial (first) phase of insulin secretion and inefficient insulin synthesis are seen years prior to the onset of type 2 diabetes. Later, it is the failure of beta cells to adequately respond to the demand for high insulin requirements that determines the onset of hyperglycaemia leading to the clinical diagnosis of type 2 diabetes. In this chapter, we will discuss the various proposed mechanisms of beta-cell failure in type 2 diabetes and address recent controversies in this field of research.

Type Book section
Authors Gunton, J.; Girgis, C. M.
Publisher Name Modern Epidemic: Expert Perspectives on Obesity and Diabetes
Published Date 2012-12-01 00:00:00
Published Pages 87-104
Status Published in-print
URL link to publisher's version <Go to ISI>://WOS:000313584600007
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11694