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B cell localization: regulation by EBI2 and its oxysterol ligand

Abstract

During antibody responses, B cells undergo a series of migratory events that guide them to microenvironments that support their activation and differentiation. Recent studies have identified Epstein-Barr virus-induced molecule 2 (EBI2 = GPR183) to be a key chemotactic receptor guiding B cell localization. EBI2 and its ligand, 7?,25-dihydroxycholesterol, direct the migration of activated B cells to interfollicular and outer follicular regions of secondary lymphoid tissues. Moreover, modulation of EBI2 expression is crucial for the generation of extrafollicular plasma cell responses and germinal center formation. Here we review the current findings that have delineated the function of EBI2 and its ligand and discuss how they collaborate with conventional lymphoid chemokine systems to position B cells optimally during immune responses.

Type Journal
Authors Gatto, D; Brink, R
Responsible Garvan Author
Publisher Name TRENDS IN IMMUNOLOGY
Published Date 2013-07-01 00:00:00
Published Volume 34
Published Issue 7
Published Pages 336-41
Status Published in-print
DOI 10.1016/j.it.2013.01.007
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/23481574
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11708