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Interleukin-27 signaling promotes immunity against endogenously arising murine tumors

Abstract

Interleukin-27 (IL-27) is a pleiotropic cytokine but its immunosuppressive effects predominate during many in vivo immunological challenges. Despite this, evidence from tumor cell line transfer models suggested that IL-27 could promote immune responses in the tumor context. However, the role of IL-27 in immunity against tumors that develop in situ and in tumor immunosurveillance remain undefined. In this study, we demonstrate that tumor development and growth are accelerated in IL-27 receptor alpha (Il27ra)-deficient mice. Enhanced tumor growth in both carcinogen-induced fibrosarcoma and oncogene-driven mammary carcinoma was associated with decreased interferon-gamma production by CD4 and CD8 T cells and increased numbers of regulatory T-cells (Treg). This is the first study to show that IL-27 promotes protective immune responses against endogenous tumors, which is critical as the basis for future development of an IL-27 based therapeutic agent.

Type Journal
Authors Natividad, K. D.: Junankar, S. R.: Mohd Redzwan, N.: Nair, R.: Wirasinha, R. C.: King, C.: Brink, R.: Swarbrick, A.: Batten, M.:
Responsible Garvan Author Dr Marcel Batten
Publisher Name PLoS One
Published Date 2013-03-14
Published Volume 8
Published Issue 3
Published Pages e57469
Status Published in-print
DOI 10.1371/journal.pone.0057469
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/23554861
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11713