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Chronic pancreatitis: A path to pancreatic cancer


Chronic pancreatitis predisposes to pancreatic cancer development and both diseases share a common etiology. A central role has been proposed for the digestive enzyme-secreting acinar cell that can undergo ductal metaplasia in the inflammatory environment of pancreatitis. This metaplastic change is now a recognised precursor of pancreatic cancer. Inflammatory molecules also foster tumour growth through autocrine and paracrine effects in the epithelium and the stroma. These insights have raised new opportunities such as the manipulation of inflammation as a preventive and/or therapeutic strategy for pancreatic cancer. Finally, we address the need for an in-depth study of the pancreatic acinar cells.

Type Journal
Authors Pinho, A. V.; Chantrill, L.; Rooman, I.
Published Date 2014-01-01
Published Volume S0304-3835
Published Issue 13
Published Pages 00590-9
Status Published in-print
DOI 10.1016/j.canlet.2013.08.015
URL link to publisher's version
OpenAccess link to author's accepted manuscript version