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Could the properties of IL-27 make it an ideal adjuvant for anticancer immunotherapy?

Abstract

We have recently been the first to demonstrate that interleukin (IL)-27 protects against the emergence and progression of autochthonous tumors. Accumulating evidence suggests that IL-27 might be uniquely well positioned to amplify beneficial TH1 anticancer immune responses while suppressing the unwanted accumulation of regulatory T cells.

Type Journal
ISBN 2162-4011 (Print)
Authors Swarbrick, A.; Junankar, S. R.; Batten, M.;
Responsible Garvan Author A/Prof Alex Swarbrick
Publisher Name Oncoimmunology
Published Date 2013-08-01
Published Volume 2
Published Issue 8
Published Pages e25409
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/24083081
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11889