Publications

Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

Structural organization and chromosomal localization of three human galanin receptor genes

Abstract

Human galanin receptor subtypes GALR1, GALR2, and GALR3 are encoded by separate genes that are located on human chromosomes 18q23, 17q25.3, and 22q13.1, respectively. The exon:intron organization of the gene encoding GALR2 (GALNR2) and GALR3 (GALNR3) is conserved, with exon 1 encoding the NH2-terminus to the end of transmembrane domain 3 and exon 2 encoding the remainder of the receptor, from the second intracellular loop to the COOH-terminus. This conservation of structural organization is indicative of a common evolutionary origin for GALNR2 and GALNR3. The exon:intron organization of the gene encoding GALR1 (GALNR1) is different from that of GALNR2 and GALNR3, with exon 1 encoding the NH2-terminus to the end of transmembrane domain 5, exon 2 encoding the third intracellular loop, and exon 3 encoding the remainder of the receptor, from transmembrane domain 6 to the COOH-terminus. The structural organization of GALNR1 suggests convergent evolution for this gene and represents a structural organization that is unique among genes encoding G-protein-coupled receptors.

Type Journal
ISBN 0077-8923 (Print)
Authors Iismaa, T. P.;Fathi, Z.;Hort, Y. J.;Iben, L. G.;Dutton, J. L.;Baker, E.;Sutherland, G. R.;Shine, J. :
Responsible Garvan Author Prof John Shine
Publisher Name Annals of the New York Academy of Sciences
Published Date 1998-01-01 00:00:00
Published Volume 863
Published Pages 56-63
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9928159
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/1194