Contribution of bone marrow derived cells to the pancreatic tumor microenvironment
Pancreatic cancer is a complex, aggressive, and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor microenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these stromal cells is not well-understood. This review examines the contribution of bone marrow-derived cells (BMDC) to pancreatic carcinogenesis, with respect to their role in constituting the tumor microenvironment. In particular, their role in supporting fibrosis, immunosuppression, and neovascularization will be discussed.
|ISBN||1664-042X (Electronic) 1664-042X (Linking)|
|Authors||Scarlett, C. J.;|
|Responsible Garvan Author|
|Publisher Name||Frontiers in Physiology|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/23531764|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/11979|