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Contribution of bone marrow derived cells to the pancreatic tumor microenvironment

Abstract

Pancreatic cancer is a complex, aggressive, and heterogeneous malignancy driven by the multifaceted interactions within the tumor microenvironment. While it is known that the tumor microenvironment accommodates many cell types, each playing a key role in tumorigenesis, the major source of these stromal cells is not well-understood. This review examines the contribution of bone marrow-derived cells (BMDC) to pancreatic carcinogenesis, with respect to their role in constituting the tumor microenvironment. In particular, their role in supporting fibrosis, immunosuppression, and neovascularization will be discussed.

Type Journal
ISBN 1664-042X (Electronic) 1664-042X (Linking)
Authors Scarlett, C. J.;
Responsible Garvan Author
Publisher Name Frontiers in Physiology
Published Date 2013-04-01
Published Volume 4
Published Pages 56
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/23531764
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/11979