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Follicular dendritic cells: origin, phenotype, and function in health and disease

Abstract

Follicular dendritic cells (FDCs) were originally identified by their specific morphology and by their ability to trap immune-complexed antigen in B cell follicles. By virtue of the latter as well as the provision of chemokines, adhesion molecules, and trophic factors, FDCs participate in the shaping of B cell responses. Importantly, FDCs also supply tingible body macrophages (TBMs) with the eat-me-signaling molecule milk fat globule-EGF factor 8 (Mfge8), thereby enabling the disposal of apoptotic B cells. Recent studies have provided fundamental insights into the multiple functions of FDCs in both physiological and pathophysiological contexts and into their origin. Here we review these findings, and discuss current concepts related to FDC histogenesis both in lymphoid organs and in inflammatory lymphoneogenesis.

Type Journal
Authors Aguzzi, A.; Kranich, J.; Krautler, N. J.
Responsible Garvan Author
Publisher Name TRENDS IN IMMUNOLOGY
Published Date 2014-03-01
Published Volume 35
Published Pages 105-113
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/24315719
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/12059