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An N-ethyl-N-nitrosourea induced Corticotropin releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.

Abstract

Mammalian Genetics Unit (L.B., C.T.E., R.A.H., S.D.M.B., R.D.C.) and Mary Lyon Centre (C.L.S., T.A.H.), Medical Research Council Harwell, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, United Kingdom; Academic Endocrine Unit (C.T.E., M.A.N., R.A.H., F.M.H., R.V.T.), Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford OX3 7LE, United Kingdom; The Mellanby Centre for Bone Research (H.E., D.L.), Department of Human Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom; Wellcome Trust Sanger Institute (C.P.), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom; Norwich Medical School (W.D.F.), University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom; Garvan Institute of Medical Research (P.I.C.), Musculoskeletal Medicine Division, University of New South Wales, Sydney 2010, Australia; and University of Queensland Diamantina Institute (M.A.B.), Princess Alexandra Hospital, University of Queensland, Brisbane 4102, Australia.

Type Journal
Authors Bentley, L.; Esapa, C.T.; Nesbit, M.A.; Head, R.A.; Evans, H.; Lath, D.; Scudamore, C.L.; Hough, T.A.; Podrini, C.; Hannan, F.M.; Fraser, W.D.; Croucher, P.I.; Brown, M.A.; Brown, S.D.; Cox, R.D.; Thakker, R.V.
Publisher Name ENDOCRINOLOGY
Published Date 2014-03-01 00:00:00
Published Volume 155
Published Issue 3
Published Pages 908-22
URL http://www.ncbi.nlm.nih.gov/pubmed/24302625
Status Published in-print