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Epigenetic biomarkers in prostate cancer: Current and future uses


Epigenome alterations are characteristic of nearly all human malignancies and include changes in DNA methylation, histone modifications and microRNAs (miRNAs). However, what induces these epigenetic alterations in cancer is largely unknown and their mechanistic role in prostate tumorigenesis is just beginning to be evaluated. Identification of the epigenetic modifications involved in the development and progression of prostate cancer will not only identify novel therapeutic targets but also prognostic and diagnostic markers. This review will focus on the use of epigenetic modifications as biomarkers for prostate cancer.

Type Journal
ISBN 1872-7980 (Electronic) 0304-3835 (Linking)
Authors Chiam, K. ; Ricciardelli, C. ; Bianco-Miotto, T.;
Published Date 2014-01-01
Published Volume 342
Published Issue 2
Published Pages 248-56
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version