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Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons


Neuropeptide Y (NPY) and noradrenaline are commonly co-expressed in sympathetic neurons. Both are key regulators of energy homeostasis and critical for stress-coping. However, little is known about the specific function of NPY in the catecholaminergic system in these regulations. Here we show that mice with NPY expression only in the noradrenergic and adrenergic cells of the catecholaminergic system (catNPY) exhibited exacerbated diet-induced obesity, lower body and brown adipose tissue temperatures compared to WT and NPY(-/-) mice under a HFD. Furthermore, chronic stress increased adiposity and serum corticosterone level in WT but not NPY(-/-) mice. Re-introducing NPY specifically to the catecholaminergic system in catNPY mice restored stress responsiveness associated with increased respiratory exchange ratio and decreased liver pACC to tACC ratio. These results demonstrate catecholaminergic NPY signalling is critical in mediating diet- and chronic stress-induced fat gain via effects on diet-induced thermogenesis and stress-induced increases in corticosterone levels and lipogenic capacity.

Type Journal
Authors Zhang, L.; Lee, I-C.J.; Enriquez, R.F.; Lau, J.; Vahatalo, L.; Baldock, P.; Savontaus, E.; Herzog, H.
Responsible Garvan Author Dr Lei Zhang
Publisher Name Molecular Metabolism
Published Date 2014-08-01
Published Volume 3
Published Issue 5
Published Pages 581-91
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version