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Thinking small: challenges and opportunities for non-antibody scaffold drugs

Abstract

The first candidates from the promising class of small non-antibody protein scaffolds are now moving into clinical development and practice. Challenges remain, and scaffolds will need to be further tailored toward applications where they provide real advantages over established therapeutics to succeed in a rapidly evolving drug development landscape.

Type Journal
Authors Vazquez-Lombardi, R.; Phan, T. G.; Zimmermann, C.; Lowe, D.; Jermutus, L.; Christ, D.
Responsible Garvan Author A/Prof Daniel Christ
Publisher Name DRUG DISCOVERY TODAY
Published Date 2015-10-20
Published Volume 10
Published Issue 1016
Published Pages 1271-83
Status Published in-print
DOI 10.1016/j.drudis.2015.09.004
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/26360055
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/12290