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RB1-mediated cell-autonomous and host-dependent oncosuppressor mechanisms in radiation-induced osteosarcoma


The mechanisms by which retinoblastoma 1 (RB1) mediates oncosuppressive functions are still being elucidated. We found that radiation-induced senescence in the bone depends on RB1 and is associated with the secretion of multiple bioactive factors, including interleukin-6 (IL-6), as well as with the infiltration of natural killer T (NKT) cells. Importantly, the inhibition of RB1, IL-6 or NKT cells predisposed mice to radiation-induced osteosarcomas, unveiling a cancer cell-extrinsic mechanisms that underlie the oncosuppressive activity of RB1.

Type Journal
ISBN 2162-4011 (Print)
Authors Kansara, M.; Thomas, D. M.;
Publisher Name Oncoimmunology
Published Date 2014-01-01
Published Volume 3
Published Issue 1
Published Pages e27569
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version