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CART in the regulation of appetite and energy homeostasis


The cocaine- and amphetamine-regulated transcript (CART) has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s). However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions1,2. In this review, we focus on knowledge gained on CART’s role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

Type Journal
Authors Lau, J.; Herzog, H.
Responsible Garvan Author Prof Herbert Herzog
Publisher Name Front Neurosci
Published Date 2014-12-01
Published Volume 8
Published Pages 313
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version