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Glycemic effects and safety of L-glutamine supplementation with or without sitagliptin in Type 2 Diabetes patients-a randomized study


BACKGROUND AND AIMS: L-glutamine is an efficacious glucagon-like peptide (GLP)-1 secretagogue in vitro. When administered with a meal, glutamine increases GLP-1 and insulin excursions and reduces postprandial glycaemia in type 2 diabetes patients. The aim of the study was to assess the efficacy and safety of daily glutamine supplementation with or without the dipeptidyl peptidase (DPP)-4 inhibitor sitagliptin in well-controlled type 2 diabetes patients. METHODS: Type 2 diabetes patients treated with metformin (n = 13, 9 men) with baseline glycated hemoglobin (HbA1c) 7.1+/-0.3% (54+/-4 mmol/mol) received glutamine (15 g bd)+ sitagliptin (100 mg/d) or glutamine (15 g bd) + placebo for 4 weeks in a randomized crossover study. RESULTS: HbA1c (P = 0.007) and fructosamine (P = 0.02) decreased modestly, without significant time-treatment interactions (both P = 0.4). Blood urea increased (P<0.001) without a significant time-treatment interaction (P = 0.8), but creatinine and estimated glomerular filtration rate (eGFR) were unchanged (P>/=0.5). Red blood cells, hemoglobin, hematocrit, and albumin modestly decreased (P</=0.02), without significant time-treatment interactions (P>/=0.4). Body weight and plasma electrolytes remained unchanged (P>/=0.2). CONCLUSIONS: Daily oral supplementation of glutamine with or without sitagliptin for 4 weeks decreased glycaemia in well-controlled type 2 diabetes patients, but was also associated with mild plasma volume expansion. TRIAL REGISTRATION: NCT00673894.

Type Journal
ISBN 1932-6203 (Electronic) 1932-6203 (Linking)
Authors Samocha-Bonet, D. ; Chisholm, D. J. ; Gribble, F. M. ; Coster, A. C. ; Carpenter, K. H. ; Jones, G. R. ; Holst, J. J. ; Greenfield, J. R.;
Publisher Name PLoS One
Published Date 2014-11-01
Published Volume 9
Published Issue 11
Published Pages e113366
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version