Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

Translational biology of osteosarcoma


For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarcoma suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome.

Type Journal
ISBN 1474-1768 (Electronic) 1474-175X (Linking)
Authors Kansara, M.; Teng, M. W.; Smyth, M. J.; Thomas, D. M.;
Responsible Garvan Author Prof David Thomas
Published Date 2014-01-01
Published Volume 14
Published Issue 11
Published Pages 722-35
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version