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The mammary cellular hierarchy and breast cancer


Advances in the study of hematopoietic cell maturation have paved the way to a deeper understanding the stem and progenitor cellular hierarchy in the mammary gland. The mammary epithelium, unlike the hematopoietic cellular hierarchy, sits in a complex niche where communication between epithelial cells and signals from the systemic hormonal milieu, as well as from extra-cellular matrix, influence cell fate decisions and contribute to tissue homeostasis. We review the discovery, definition and regulation of the mammary cellular hierarchy and we describe the development of the concepts that have guided our investigations. We outline recent advances in in vivo lineage tracing that is now challenging many of our assumptions regarding the behavior of mammary stem cells, and we show how understanding these cellular lineages has altered our view of breast cancer.

Type Journal
ISBN 1420-9071 (Electronic) 1420-682X (Linking)
Authors Oakes, S. R. ; Gallego-Ortega, D. ; Ormandy, C. J.;
Responsible Garvan Author Dr Samantha Oakes
Published Date 2014-01-01
Published Volume 71
Published Issue 22
Published Pages 4301-24
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version