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Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories

Abstract

Extensive surface profiles of colorectal cancer (CRC) cells and tumor infiltrating lymphocytes (TIL) have been obtained from 45 surgical resection samples. Live cells were captured on an antibody microarray and stained with fluorescently-labeled antibodies. Minimal panels of 11 CRC antigens (CD13, CD24, CD26, CD49d, CD138, CD166, CA-125, CA19-9, EGFR, Galectin-4 and HLA-DR) and 11 T-cell antigens (CD10, CD11b, CD11c, CD25, CD31, CD95, CD151, CD181, Galectin-4, CA19-9, TSP-1) provide signatures for relapse and survival. Hierarchical clustering of profiles from CRC cells and TIL identified groups of patients for survival, systemic relapse and death. The groups from CRC and TIL profiles for systemic relapse showed 79.2% concordance, enabling prediction of relapse after surgery. The results demonstrate communication between CRC cells and TIL.

Type Journal
ISBN 1872-7905 (Electronic) 0022-1759 (Linking)
Authors Zhou, J.; Belov, L.; Chapuis, P.; Chan, C.; Armstrong, N.; Kaufman, K. L.; Solomon, M. J.; Clarke, S. J.; Christopherson, R. I.;
Publisher Name JOURNAL OF IMMUNOLOGICAL METHODS
Published Date 2015-01-01
Published Volume 416
Published Pages 59-68
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/25445327
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/12747