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Accepting risk in the acceleration of drug development for rare cancers


Rare cancers collectively contribute a disproportionate fraction of the total burden of cancer. The oncology community is increasingly facing small numbers of patients with each cancer subtype, requiring cooperation and collaboration to complete multicentre trials that advance knowledge and patient care. At the same time, new insights into the biology of rare cancers have led to an explosion in knowledge and development of targeted agents. These insights and techniques are set to revolutionise the care of patients with cancer. However, drug development strategies and the availability of new agents for rare cancers are at risk of stalling owing to the ever-increasing complexity and costs of clinical trials. Finding solutions to these problems is imperative to the future of cancer care. We propose that a greater degree of risk sharing is needed than is currently accepted to enable the use of new methods with confidence, and to keep pace with scientific advancement.

Type Journal
ISBN 1474-5488 (Electronic) 1470-2045 (Linking)
Authors Ashley, D. ; Thomas, D.M. ; Gore, L. ; Carter, R. ; Zalcberg, J. R. ; Otmar, R. ; Savulescu, J.;
Published Date 2015-01-01
Published Volume 16
Published Issue 4
Published Pages e190-194
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version