Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility


Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OAT men a precise diagnosis cannot be provided. Here we demonstrate that leucine-rich repeats and guanylate kinase-domain containing isoform 1 (LRGUK-1) is required for multiple aspects of sperm assembly, including acrosome attachment, sperm head shaping and the initiation of the axoneme growth to form the core of the sperm tail. Specifically, LRGUK-1 is required for basal body attachment to the plasma membrane, the appropriate formation of the sub-distal appendages, the extension of axoneme microtubules and for microtubule movement and organisation within the manchette. Manchette dysfunction leads to abnormal sperm head shaping. Several of these functions may be achieved in association with the LRGUK-1 binding partner HOOK2. Collectively, these data establish LRGUK-1 as a major determinant of microtubule structure within the male germ line.

Type Journal
ISBN 1553-7404 (Electronic) 1553-7390 (Linking)
Authors Liu, Y. ; DeBoer, K. ; de Kretser, D. M. ; O'Donnell, L. ; O'Connor, A. E. ; Merriner, D. J. ; Okuda, H. ; Whittle, B. ; Jans, D. A. ; Efthymiadis, A. ; McLachlan, R. I. ; Ormandy, C. J. ; Goodnow, C. C. ; Jamsai, D. ; O'Bryan, M. K.;
Publisher Name PLOS GENET
Published Date 2015-01-01
Published Volume 11
Published Issue 3
Published Pages e1005090
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version