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Regulation of energy homeostasis by the NPY system


Obesity develops when energy intake exceeds energy expenditure over time. Numerous neurotransmitters, hormones, and factors have been implicated to coordinately control energy homeostasis, centrally and peripherally. However, the neuropeptide Y (NPY) system has emerged as the one with the most critical functions in this process. While NPY centrally promotes feeding and reduces energy expenditure, peptide YY (PYY) and pancreatic polypeptide (PP), the other family members, mediate satiety. Importantly, recent research has uncovered additional functions for these peptides that go beyond the simple feeding/satiety circuits and indicate a more extensive function in controlling energy homeostasis. In this review, we will discuss the actions of the NPY system in the regulation of energy balance, with a particular focus on energy expenditure.

Type Journal
ISBN 1879-3061 (Electronic) 1043-2760 (Linking)
Authors Loh, K.; Herzog, H.; Shi, Y. C.;
Published Date 2015-01-01
Published Volume 26
Published Issue 3
Published Pages 125-35
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version