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SnapShot: insulin/IGF1 signaling

Abstract

The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy storage, apoptosis, transcription, and cellular homeostasis. Such regulation involves precise rewiring of temporal events in protein phosphorylation networks. For an animated version of this Enhanced SnapShot, please visit http://www.cell.com/cell/enhanced/odonoghue.

Type Journal
ISBN 1097-4172 (Electronic) 0092-8674 (Linking)
Authors Ma, D. K.; Stolte, C.; Krycer, J. R.; James, D. E.; O'Donoghue, S. I.;
Publisher Name CELL
Published Date 2015-01-01
Published Volume 161
Published Issue 4
Published Pages 948-948 e1
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/25957692
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/12832