SnapShot: insulin/IGF1 signaling
The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy storage, apoptosis, transcription, and cellular homeostasis. Such regulation involves precise rewiring of temporal events in protein phosphorylation networks. For an animated version of this Enhanced SnapShot, please visit http://www.cell.com/cell/enhanced/odonoghue.
|ISBN||1097-4172 (Electronic) 0092-8674 (Linking)|
|Authors||Ma, D. K.; Stolte, C.; Krycer, J. R.; James, D. E.; O'Donoghue, S. I.;|
|Published Pages||948-948 e1|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/25957692|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/12832|