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Building new function into glycine receptors: a structural model for the activation of the glycine-gated chloride channel


1. The glycine receptor chloride channel mediates inhibitory neurotransmission and is a member of the ligand-gated ion channel superfamily, which includes the nicotinic acetylcholine receptor channel. 2. Activation of these channels involves a movement of the pore-lining second membrane-spanning domain with respect to the remainder of the protein. 3. The present review considers the evidence that the loops that connect this domain with the rest of the protein act as crucial components of the channel activation mechanism.

Type Journal
ISBN 0305-1870 (Print)
Authors Lynch, J. W.;Han, N. I.;Schofield, P. R. :
Publisher Name Clin Exp Pharmacol Physiol
Published Date 1999-01-01
Published Volume 26
Published Issue 11
Published Pages 932-4
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version