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The evolution of therapies in non-small cell lung cancer

Abstract

The landscape of advanced non-small lung cancer (NSCLC) therapies has rapidly been evolving beyond chemotherapy over the last few years. The discovery of oncogenic driver mutations has led to new ways in classifying NSCLC as well as offered novel therapeutic targets for anticancer therapy. Targets such as epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) gene rearrangements have successfully been targeted with appropriate tyrosine kinase inhibitors (TKIs). Other driver mutations such as ROS, MET, RET, BRAF have also been investigated with targeted agents with some success in the early phase clinical setting. Novel strategies in the field of immune-oncology have also led to the development of inhibitors of cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed death-1 receptor (PD-1), which are important pathways in allowing cancer cells to escape detection by the immune system. These inhibitors have been successfully tried in NSCLC and also now bring the exciting possibility of long term responses in advanced NSCLC. In this review recent data on novel targets and therapeutic strategies and their future prospects are discussed.

Type Journal
ISBN 2072-6694 (Electronic) 2072-6694 (Linking)
Authors Boolell, V.; Alamgeer, M.; Watkins, D. N.; Ganju, V.;
Responsible Garvan Author Prof Neil Watkins
Publisher Name Cancers
Published Date 2015-01-01
Published Volume 7
Published Issue 3
Published Pages 1815-1846
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/26371045
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/12976