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Patient-centric trials for therapeutic development in precision oncology

Abstract

An enhanced understanding of the molecular pathology of disease gained from genomic studies is facilitating the development of treatments that target discrete molecular subclasses of tumours. Considerable associated challenges include how to advance and implement targeted drug-development strategies. Precision medicine centres on delivering the most appropriate therapy to a patient on the basis of clinical and molecular features of their disease. The development of therapeutic agents that target molecular mechanisms is driving innovation in clinical-trial strategies. Although progress has been made, modifications to existing core paradigms in oncology drug development will be required to realize fully the promise of precision medicine.

Type Journal
Authors Biankin, A. V.; Piantadosi, S.; Hollingsworth, S. J.
Responsible Garvan Author
Publisher Name NATURE
Published Date 2015-01-01
Published Volume 526
Published Issue 7573
Published Pages 361-370
Status Published in-print
DOI 10.1038/nature15819
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/26469047
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/12989