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Carrier solutions for low-level intravenous insulin infusion


In the use of low-level intravenous insulin infusion for treating diabetic hyperglycaemia and ketoacidosis adsorption of insulin to containers or plastic infusion apparatus results in significant losses of 60-80% of insulin in dilute physiological saline solution (40 U/l). It is therefore necessary to add protein to the carrier solution to minimize losses and maintain a constant delivery rate. Recovery studies showed that 3.5% w/v polygeline solution (polymer of degraded gelatin) was a suitable medium for this purpose, offering some advantages over human serum albumin. A minimum concentration of 0.5% polygeline was required to ensure adequate delivery of insulin to the patient.

Type Journal
ISBN 0007-1447 (Print)
Authors Kraegen, E. W.;Lazarus, L.;Meler, H.;Campbell, L.;Chia, Y. O. :
Responsible Garvan Author Prof Edward Kraegen
Publisher Name BRIT MED J
Published Date 1975-01-01
Published Volume 3
Published Issue 5981
Published Pages 464-6
Status Published in-print
URL link to publisher's version