Carrier solutions for low-level intravenous insulin infusion
In the use of low-level intravenous insulin infusion for treating diabetic hyperglycaemia and ketoacidosis adsorption of insulin to containers or plastic infusion apparatus results in significant losses of 60-80% of insulin in dilute physiological saline solution (40 U/l). It is therefore necessary to add protein to the carrier solution to minimize losses and maintain a constant delivery rate. Recovery studies showed that 3.5% w/v polygeline solution (polymer of degraded gelatin) was a suitable medium for this purpose, offering some advantages over human serum albumin. A minimum concentration of 0.5% polygeline was required to ensure adequate delivery of insulin to the patient.
|Authors||Kraegen, E. W.;Lazarus, L.;Meler, H.;Campbell, L.;Chia, Y. O. :|
|Responsible Garvan Author|
|Publisher Name||BRIT MED J|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1156820|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/130|