Carrier solutions for low-level intravenous insulin infusion
In the use of low-level intravenous insulin infusion for treating diabetic hyperglycaemia and ketoacidosis adsorption of insulin to containers or plastic infusion apparatus results in significant losses of 60-80% of insulin in dilute physiological saline solution (40 U/l). It is therefore necessary to add protein to the carrier solution to minimize losses and maintain a constant delivery rate. Recovery studies showed that 3.5% w/v polygeline solution (polymer of degraded gelatin) was a suitable medium for this purpose, offering some advantages over human serum albumin. A minimum concentration of 0.5% polygeline was required to ensure adequate delivery of insulin to the patient.
|Authors||Kraegen, E. W.;Lazarus, L.;Meler, H.;Campbell, L.;Chia, Y. O. :|
|Publisher Name||BRIT MED J|
|Published Date||1975-01-01 00:00:00|