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Interplay between Transcription Factors and the Epigenome: Insight from the Role of RUNX1 in Leukemia


The genome has the ability to respond in a precise and co-ordinated manner to cellular signals. It achieves this through the concerted actions of transcription factors and the chromatin platform, which are targets of the signaling pathways. Our understanding of the molecular mechanisms through which transcription factors and the chromatin landscape each control gene activity has expanded dramatically over recent years, and attention has now turned to understanding the complex, multifaceted interplay between these regulatory layers in normal and disease states. It has become apparent that transcription factors as well as the components and modifiers of the epigenetic machinery are frequent targets of genomic alterations in cancer cells. Through the study of these factors, we can gain unique insight into the dynamic interplay between transcription factors and the epigenome, and how their dysregulation leads to aberrant gene expression programs in cancer. Here, we will highlight how these factors normally co-operate to establish and maintain the transcriptional and epigenetic landscape of cells, and how this is reprogramed in cancer, focusing on the RUNX1 transcription factor and oncogenic derivative RUNX1-ETO in leukemia as paradigms of transcriptional and epigenetic reprograming.

Type Journal
ISBN 1664-3224 (Electronic) 1664-3224 (Linking)
Authors Brettingham-Moore, K. H. ; Taberlay, P. C. ; Holloway, A. F.;
Responsible Garvan Author (missing name)
Publisher Name Frontiers in Immunology
Published Date 2015-01-01
Published Volume 6
Published Pages 499
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version