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Bone muscle interactions and vitamin D


Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases. This article is part of a Special Issue entitled

Type Journal
ISBN 1873-2763 (Electronic) 1873-2763 (Linking)
Authors Gunton, J. E. ; Girgis, C. M. ; Baldock, P. A. ; Lips, P.;
Responsible Garvan Author (missing name)
Publisher Name BONE
Published Date 2015-01-01
Published Volume 80
Published Pages 89-94
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version