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Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans

Abstract

Humans maintain core temperature through a complex neuroendocrine circuitry, coupling environmental thermal and nutritional cues to heat-producing and dissipating mechanisms. Up to 40% of resting energy expenditure contributes to thermal homeostasis maintenance. Recent re-discovery of thermogenic brown adipose tissue (BAT) has brought the relation between ambient temperature, thermogenesis and systemic energy and substrate metabolism to the forefront. In addition to well-known pituitary-thyroid-adrenal axis, new endocrine signals, such as FGF21 and irisin, orchestrate crosstalk between white adipose tissue (WAT), BAT and muscle, tuning non-shivering and shivering thermogenesis responses. Cold exposure modulates the endocrine milieu, and cold-induced hormones cause bioenergetics transformation sufficient to impact whole body metabolism. This review will appraise the nature of human BAT and the basis of BAT-centred therapeutics, highlighting how the interaction between hormones and adipose tissue impacts metabolic responses. Non-pharmacological and pharmacological strategies of BAT recruitment and/or fat browning for metabolic benefits will be discussed.

Type Journal
ISBN 1872-8057 (Electronic) 0303-7207 (Linking)
Authors Lee, P.?; Greenfield, J. R.;
Garvan Authors
Publisher Name MOL CELL ENDOCRINOL
Published Date 2015-12-15 00:00:00
Published Volume 418 Pt 2
Published Pages 184-90
URL http://www.ncbi.nlm.nih.gov/pubmed/26026310
Status Published in-print